Sensitivity of small myosin II ensembles from different isoforms to mechanical load and ATP concentration
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چکیده
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Sensitivity of small myosin II ensembles from different isoforms to mechanical load and ATP concentration.
Based on a detailed crossbridge model for individual myosin II motors, we systematically study the influence of mechanical load and adenosine triphosphate (ATP) concentration on small myosin II ensembles made from different isoforms. For skeletal and smooth muscle myosin II, which are often used in actomyosin gels that reconstitute cell contractility, fast forward movement is restricted to a sm...
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15 صفحه اولHow actin-myosin interactions differ with different isoforms of myosin.
The development of in vitro techniques for assaying the mechanical properties of individual actin-myosin interactions has provided investigators with a powerful tool to address questions about fundamental properties of the force-generating reactions that produce movement of cells or organelles within cells. These techniques are capable of measuring the force and/or displacement produced by the ...
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ژورنال
عنوان ژورنال: Physical Review E
سال: 2016
ISSN: 2470-0045,2470-0053
DOI: 10.1103/physreve.94.052403